Caesium in PDB 6wcb: Human Open State TMEM175 in Cscl

The binding sites of Caesium atom in the Human Open State TMEM175 in Cscl (pdb code 6wcb). This binding sites where shown within 5.0 Angstroms radius around Caesium atom.
In total 7 binding sites of Caesium where determined in the Human Open State TMEM175 in Cscl, PDB code: 6wcb:
Jump to Caesium binding site number: 1; 2; 3; 4; 5; 6; 7;

Caesium binding site 1 out of 7 in the Human Open State TMEM175 in Cscl


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 1 of Human Open State TMEM175 in Cscl within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs701 b:0.4 occ:1.00 HB2 A:ALA263 3.0 34.9 1.0 CS B:CS701 3.5 0.1 1.0 HG A:SER38 3.5 38.0 1.0 OG A:SER38 3.5 38.0 1.0 HB3 A:SER38 3.6 38.0 1.0 O A:HOH816 3.6 36.2 1.0 HB1 A:ALA263 3.6 34.9 1.0 CB A:ALA263 3.7 34.9 1.0 O A:HOH811 3.7 37.0 1.0 O B:HOH804 3.8 44.2 1.0 O A:HOH806 4.0 38.7 1.0 CB A:SER38 4.0 38.0 1.0 HG B:SER38 4.1 38.3 1.0 O A:HOH817 4.1 39.7 1.0 HA A:ALA263 4.1 34.9 1.0 HA A:SER38 4.2 38.0 1.0 O A:HOH804 4.2 43.7 1.0 HB3 B:SER38 4.3 38.3 1.0 HB3 A:ALA263 4.4 34.9 1.0 CA A:ALA263 4.5 34.9 1.0 OG B:SER38 4.7 38.3 1.0 CA A:SER38 4.7 38.0 1.0 HB2 A:SER38 4.9 38.0 1.0 CB B:SER38 4.9 38.3 1.0

Caesium binding site 2 out of 7 in the Human Open State TMEM175 in Cscl


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 2 of Human Open State TMEM175 in Cscl within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs702 b:0.9 occ:1.00 HA3 A:GLY267 3.0 36.1 1.0 HA2 A:GLY267 3.0 36.1 1.0 HA A:ALA42 3.1 36.5 1.0 HB2 A:ALA42 3.2 36.5 1.0 CA A:GLY267 3.4 36.1 1.0 CS B:CS702 3.5 0.3 1.0 HB1 A:ALA42 3.6 36.5 1.0 CB A:ALA42 3.7 36.5 1.0 O A:HOH819 3.8 38.4 1.0 CA A:ALA42 3.8 36.5 1.0 H A:GLY267 3.8 36.1 1.0 N A:GLY267 3.9 36.1 1.0 HB2 B:ALA42 3.9 36.7 1.0 O A:HOH811 3.9 37.0 1.0 HB1 B:ALA42 4.0 36.7 1.0 OG A:SER45 4.1 35.0 1.0 O A:HOH817 4.1 39.7 1.0 O A:ALA263 4.2 34.9 1.0 HG A:SER45 4.3 35.0 1.0 CB B:ALA42 4.4 36.7 1.0 N A:ALA42 4.5 36.5 1.0 O B:HOH819 4.6 38.5 1.0 HB3 A:ALA42 4.6 36.5 1.0 H A:ALA42 4.8 36.5 1.0 C A:GLY267 4.8 36.1 1.0 C A:ASP266 4.8 36.0 1.0 HB2 A:ASP266 4.8 36.0 1.0 C A:ALA42 4.9 36.5 1.0 HB3 B:ALA42 5.0 36.7 1.0

Caesium binding site 3 out of 7 in the Human Open State TMEM175 in Cscl


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 3 of Human Open State TMEM175 in Cscl within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs703 b:0.5 occ:1.00 HD13 A:LEU53 3.4 49.8 1.0 HD23 A:LEU275 3.4 44.1 1.0 HD23 A:LEU278 3.5 45.2 1.0 CS B:CS703 3.5 0.6 1.0 HD22 A:LEU278 3.6 45.2 1.0 HG23 A:ILE271 3.6 38.4 1.0 HD21 A:LEU53 3.6 49.8 1.0 O A:HOH803 3.7 42.6 1.0 HD21 A:LEU275 3.8 44.1 1.0 CD2 A:LEU278 3.9 45.2 1.0 O A:HOH808 4.0 39.2 1.0 HD23 B:LEU278 4.0 45.3 1.0 HD21 A:LEU278 4.1 45.2 1.0 CD2 A:LEU275 4.1 44.1 1.0 HD21 B:LEU278 4.1 45.3 1.0 CS A:CS704 4.2 0.3 1.0 HG21 A:ILE271 4.3 38.4 1.0 CD1 A:LEU53 4.3 49.8 1.0 CG2 A:ILE271 4.4 38.4 1.0 CD2 B:LEU278 4.5 45.3 1.0 CD2 A:LEU53 4.5 49.8 1.0 HG A:LEU275 4.5 44.1 1.0 HA A:LEU275 4.6 44.1 1.0 HG A:LEU53 4.8 49.8 1.0 HD12 A:LEU53 4.8 49.8 1.0 HD22 A:LEU275 4.8 44.1 1.0 HG12 A:ILE271 4.8 38.4 1.0 CG A:LEU53 4.8 49.8 1.0 HG22 A:ILE271 4.9 38.4 1.0 HD22 A:LEU53 4.9 49.8 1.0 HD11 A:LEU53 4.9 49.8 1.0 HD22 B:LEU278 4.9 45.3 1.0 CG A:LEU275 4.9 44.1 1.0

Caesium binding site 4 out of 7 in the Human Open State TMEM175 in Cscl


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 4 of Human Open State TMEM175 in Cscl within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs704 b:0.3 occ:1.00 HG12 B:ILE271 3.0 38.6 1.0 HG12 A:ILE271 3.0 38.4 1.0 HG12 A:ILE46 3.1 38.2 1.0 HG12 B:ILE46 3.1 38.5 1.0 CG1 B:ILE271 3.9 38.6 1.0 CG1 A:ILE271 3.9 38.4 1.0 CG1 A:ILE46 4.0 38.2 1.0 HD13 A:ILE46 4.0 38.2 1.0 HD11 B:ILE271 4.0 38.6 1.0 HD11 A:ILE271 4.0 38.4 1.0 CG1 B:ILE46 4.0 38.5 1.0 HD13 B:ILE46 4.0 38.5 1.0 HD13 A:ILE271 4.2 38.4 1.0 HD13 B:ILE271 4.2 38.6 1.0 HD11 A:ILE46 4.2 38.2 1.0 HG13 B:ILE271 4.2 38.6 1.0 HD11 B:ILE46 4.2 38.5 1.0 HG21 A:ILE46 4.2 38.2 1.0 CS A:CS703 4.2 0.5 1.0 HG23 A:ILE46 4.2 38.2 1.0 HG13 A:ILE271 4.2 38.4 1.0 CD1 B:ILE271 4.3 38.6 1.0 CS B:CS703 4.3 0.6 1.0 CD1 A:ILE271 4.3 38.4 1.0 HG21 B:ILE46 4.3 38.5 1.0 CD1 A:ILE46 4.3 38.2 1.0 HG23 B:ILE46 4.3 38.5 1.0 O B:HOH819 4.3 38.5 1.0 CD1 B:ILE46 4.3 38.5 1.0 O A:HOH819 4.3 38.4 1.0 HG23 B:ILE271 4.5 38.6 1.0 HG23 A:ILE271 4.5 38.4 1.0 HG13 A:ILE46 4.5 38.2 1.0 HG13 B:ILE46 4.5 38.5 1.0 CG2 A:ILE46 4.6 38.2 1.0 O B:HOH803 4.7 42.4 1.0 CG2 B:ILE46 4.7 38.5 1.0 HG21 A:ILE271 4.7 38.4 1.0 O A:HOH803 4.7 42.6 1.0 HG21 B:ILE271 4.7 38.6 1.0 HA B:ILE271 4.8 38.6 1.0 O A:HOH808 4.8 39.2 1.0 HA A:ILE271 4.8 38.4 1.0 O B:HOH807 4.8 39.7 1.0 CB A:ILE46 4.9 38.2 1.0 CG2 B:ILE271 4.9 38.6 1.0 CG2 A:ILE271 4.9 38.4 1.0 CB B:ILE271 4.9 38.6 1.0 HA A:ILE46 5.0 38.2 1.0 CB B:ILE46 5.0 38.5 1.0 CB A:ILE271 5.0 38.4 1.0 HD21 B:LEU278 5.0 45.3 1.0 HD21 A:LEU278 5.0 45.2 1.0 HA B:ILE46 5.0 38.5 1.0

Caesium binding site 5 out of 7 in the Human Open State TMEM175 in Cscl


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 5 of Human Open State TMEM175 in Cscl within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs701 b:0.1 occ:1.00 HB2 B:ALA263 3.0 35.1 1.0 CS A:CS701 3.5 0.4 1.0 HG B:SER38 3.5 38.3 1.0 OG B:SER38 3.5 38.3 1.0 HB3 B:SER38 3.6 38.3 1.0 O B:HOH816 3.6 35.0 1.0 HB1 B:ALA263 3.6 35.1 1.0 CB B:ALA263 3.7 35.1 1.0 O B:HOH811 3.7 37.7 1.0 O A:HOH804 3.9 43.7 1.0 O B:HOH806 4.0 39.4 1.0 CB B:SER38 4.0 38.3 1.0 HG A:SER38 4.1 38.0 1.0 O B:HOH817 4.1 39.3 1.0 HA B:ALA263 4.1 35.1 1.0 HB3 A:SER38 4.2 38.0 1.0 O B:HOH804 4.2 44.2 1.0 HA B:SER38 4.2 38.3 1.0 HB3 B:ALA263 4.4 35.1 1.0 CA B:ALA263 4.5 35.1 1.0 OG A:SER38 4.7 38.0 1.0 CA B:SER38 4.7 38.3 1.0 HB2 B:SER38 4.9 38.3 1.0 CB A:SER38 4.9 38.0 1.0

Caesium binding site 6 out of 7 in the Human Open State TMEM175 in Cscl


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 6 of Human Open State TMEM175 in Cscl within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs702 b:0.3 occ:1.00 HA3 B:GLY267 3.0 36.4 1.0 HA2 B:GLY267 3.0 36.4 1.0 HA B:ALA42 3.1 36.7 1.0 HB2 B:ALA42 3.2 36.7 1.0 CA B:GLY267 3.4 36.4 1.0 CS A:CS702 3.5 0.9 1.0 HB1 B:ALA42 3.6 36.7 1.0 CB B:ALA42 3.7 36.7 1.0 O B:HOH819 3.8 38.5 1.0 CA B:ALA42 3.8 36.7 1.0 H B:GLY267 3.8 36.4 1.0 N B:GLY267 3.9 36.4 1.0 HB2 A:ALA42 3.9 36.5 1.0 O B:HOH811 3.9 37.7 1.0 HB1 A:ALA42 3.9 36.5 1.0 OG B:SER45 4.1 35.2 1.0 O B:HOH817 4.2 39.3 1.0 O B:ALA263 4.2 35.1 1.0 HG B:SER45 4.3 35.2 1.0 CB A:ALA42 4.4 36.5 1.0 O A:HOH819 4.5 38.4 1.0 N B:ALA42 4.5 36.7 1.0 HB3 B:ALA42 4.6 36.7 1.0 H B:ALA42 4.8 36.7 1.0 C B:GLY267 4.8 36.4 1.0 C B:ASP266 4.8 35.9 1.0 HB2 B:ASP266 4.8 35.9 1.0 C B:ALA42 4.9 36.7 1.0 HB3 A:ALA42 5.0 36.5 1.0

Caesium binding site 7 out of 7 in the Human Open State TMEM175 in Cscl


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 7 of Human Open State TMEM175 in Cscl within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs703 b:0.6 occ:1.00 HD13 B:LEU53 3.4 50.0 1.0 HD23 B:LEU275 3.4 44.1 1.0 HD23 B:LEU278 3.5 45.3 1.0 CS A:CS703 3.5 0.5 1.0 HD22 B:LEU278 3.6 45.3 1.0 HG23 B:ILE271 3.6 38.6 1.0 HD21 B:LEU53 3.6 50.0 1.0 O B:HOH803 3.7 42.4 1.0 HD21 B:LEU275 3.8 44.1 1.0 CD2 B:LEU278 3.9 45.3 1.0 O B:HOH807 4.0 39.7 1.0 HD23 A:LEU278 4.0 45.2 1.0 HD21 B:LEU278 4.1 45.3 1.0 CD2 B:LEU275 4.1 44.1 1.0 HD21 A:LEU278 4.1 45.2 1.0 CS A:CS704 4.3 0.3 1.0 HG21 B:ILE271 4.3 38.6 1.0 CD1 B:LEU53 4.3 50.0 1.0 CG2 B:ILE271 4.4 38.6 1.0 CD2 A:LEU278 4.5 45.2 1.0 CD2 B:LEU53 4.5 50.0 1.0 HG B:LEU275 4.5 44.1 1.0 HA B:LEU275 4.6 44.1 1.0 HG B:LEU53 4.8 50.0 1.0 HD12 B:LEU53 4.8 50.0 1.0 HD22 B:LEU275 4.8 44.1 1.0 HG12 B:ILE271 4.8 38.6 1.0 CG B:LEU53 4.8 50.0 1.0 HG22 B:ILE271 4.9 38.6 1.0 HD22 B:LEU53 4.9 50.0 1.0 HD11 B:LEU53 4.9 50.0 1.0 HD22 A:LEU278 4.9 45.2 1.0 CG B:LEU275 4.9 44.1 1.0

S.Oh, N.Paknejad, R.K.Hite. Gating and Selectivity Mechanisms For the Lysosomal K+Channel TMEM175. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 32228865
DOI: 10.7554/ELIFE.53430