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Caesium in PDB 2x1w: Crystal Structure of Vegf-C in Complex with Domains 2 and 3 of VEGFR2

Protein crystallography data

The structure of Crystal Structure of Vegf-C in Complex with Domains 2 and 3 of VEGFR2, PDB code: 2x1w was solved by V.M.Leppanen, A.E.Prota, M.Jeltsch, A.Anisimov, N.Kalkkinen, T.Strandin, H.Lankinen, A.Goldman, K.Ballmer-Hofer, K.Alitalo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.958 / 2.70
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 73.750, 123.830, 211.831, 90.00, 90.00, 90.00
R / Rfree (%) 22.69 / 27.98

Caesium Binding Sites:

The binding sites of Caesium atom in the Crystal Structure of Vegf-C in Complex with Domains 2 and 3 of VEGFR2 (pdb code 2x1w). This binding sites where shown within 5.0 Angstroms radius around Caesium atom.
In total 2 binding sites of Caesium where determined in the Crystal Structure of Vegf-C in Complex with Domains 2 and 3 of VEGFR2, PDB code: 2x1w:
Jump to Caesium binding site number: 1; 2;

Caesium binding site 1 out of 2 in 2x1w

Go back to Caesium Binding Sites List in 2x1w
Caesium binding site 1 out of 2 in the Crystal Structure of Vegf-C in Complex with Domains 2 and 3 of VEGFR2


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 1 of Crystal Structure of Vegf-C in Complex with Domains 2 and 3 of VEGFR2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cs1215

b:85.5
occ:0.68
O B:THR148 3.5 71.1 1.0
OE1 A:GLU169 3.5 88.7 1.0
O B:THR150 3.7 87.2 1.0
O B:HOH2005 3.9 34.2 1.0
CG B:PHE151 4.0 90.5 1.0
CD1 B:PHE151 4.0 85.7 1.0
CB B:THR148 4.2 86.5 1.0
C B:THR148 4.2 86.3 1.0
CA B:THR148 4.2 90.6 1.0
CD2 B:PHE151 4.2 0.4 1.0
CA B:PHE151 4.2 69.1 1.0
CE1 B:PHE151 4.2 90.9 1.0
C B:THR150 4.3 63.6 1.0
OG1 B:THR148 4.3 62.5 1.0
CD A:GLU169 4.3 80.0 1.0
CE2 B:PHE151 4.3 95.1 1.0
CZ B:PHE151 4.4 92.0 1.0
CB B:PHE151 4.6 82.5 1.0
N B:PHE151 4.6 57.8 1.0
OE2 A:GLU169 4.8 66.4 1.0
N B:THR150 4.8 60.2 1.0
NZ N:LYS286 5.0 55.3 1.0

Caesium binding site 2 out of 2 in 2x1w

Go back to Caesium Binding Sites List in 2x1w
Caesium binding site 2 out of 2 in the Crystal Structure of Vegf-C in Complex with Domains 2 and 3 of VEGFR2


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 2 of Crystal Structure of Vegf-C in Complex with Domains 2 and 3 of VEGFR2 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cs1216

b:0.4
occ:1.00
O C:THR150 3.6 66.8 1.0
O C:THR148 3.8 55.2 1.0
CE1 C:PHE151 4.1 75.0 1.0
C C:THR148 4.2 38.0 1.0
O C:ALA147 4.2 59.6 1.0
CD1 C:PHE151 4.3 65.9 1.0
CA C:THR148 4.4 46.5 1.0
CZ C:PHE151 4.4 83.0 1.0
OE2 D:GLU169 4.5 0.9 1.0
CG1 C:VAL146 4.6 44.2 1.0
C C:THR150 4.7 59.7 1.0
CG C:PHE151 4.8 67.7 1.0
CE2 C:PHE151 4.9 82.0 1.0

Reference:

V.M.Leppanen, A.E.Prota, M.Jeltsch, A.Anisimov, N.Kalkkinen, T.Strandin, H.Lankinen, A.Goldman, K.Ballmer-Hofer, K.Alitalo. Structural Determinants of Growth Factor Binding and Specificity By Vegf Receptor 2. Proc.Natl.Acad.Sci.Usa V. 107 2425 2010.
ISSN: ISSN 0027-8424
PubMed: 20145116
DOI: 10.1073/PNAS.0914318107
Page generated: Sun Jul 13 22:31:11 2025

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