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Caesium in PDB 8cn9: Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII

Enzymatic activity of Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII

All present enzymatic activity of Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII:
3.4.21.21;

Protein crystallography data

The structure of Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII, PDB code: 8cn9 was solved by G.Schluckebier, E.Johansson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.50 / 3.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 144.782, 100.794, 181.739, 90, 101.22, 90
R / Rfree (%) 30.3 / 35.6

Other elements in 8cn9:

The structure of Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII also contains other interesting chemical elements:

Calcium (Ca) 10 atoms

Caesium Binding Sites:

The binding sites of Caesium atom in the Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII (pdb code 8cn9). This binding sites where shown within 5.0 Angstroms radius around Caesium atom.
In total only one binding site of Caesium was determined in the Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII, PDB code: 8cn9:

Caesium binding site 1 out of 1 in 8cn9

Go back to Caesium Binding Sites List in 8cn9
Caesium binding site 1 out of 1 in the Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 1 of Factor VII Binding Fab of the Bispecific Antibody Hmb-001 in Complex with Factor VII within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Cs301

b:115.7
occ:1.00
 OG P:SER114 3.2 98.1 1.0
O P:ALA112 3.2 68.7 1.0
O P:ASN138 3.3 78.7 1.0
O P:ASN137 3.4 59.3 1.0
CB P:ASN138 3.5 74.4 1.0
N P:SER114 4.0 57.9 1.0
C P:ASN138 4.1 65.0 1.0
C P:ALA112 4.2 54.8 1.0
CA P:ASN138 4.3 72.8 1.0
CA P:PRO113 4.3 56.8 1.0
CB P:SER114 4.4 72.1 1.0
C P:ASN137 4.4 61.5 1.0
C P:PRO113 4.4 60.5 1.0
CG P:ASN138 4.6 67.5 1.0
N P:PRO113 4.7 42.4 1.0
CA P:SER114 4.8 56.4 1.0
N P:ASN138 4.8 66.0 1.0

Reference:

P.S.Gandhi, M.Zivkovic, H.Oestergaard, A.C.Bonde, M.N.Loevgreen, G.Schluckebier, E.Johansson, C.J.Rea, B.Soerensen, R.E.Schutgens, R.T.Urbanus, J.H.Faber. A Bispecific Antibody Approach For the Potential Prophylactic Treatment of Inherited Bleeding Disorders Nat Cardiovasc Res 2023.
ISSN: ESSN 2731-0590
Page generated: Tue Jul 30 21:22:27 2024

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