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Caesium in PDB 7lut: The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution

Enzymatic activity of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution

All present enzymatic activity of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution:
4.2.1.20;

Protein crystallography data

The structure of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution, PDB code: 7lut was solved by E.Hilario, M.F.Dunn, L.J.Mueller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.28 / 1.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 182.412, 61.086, 67.063, 90, 94.86, 90
R / Rfree (%) 18.7 / 21.7

Other elements in 7lut:

The structure of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution also contains other interesting chemical elements:

Chlorine (Cl) 5 atoms

Caesium Binding Sites:

The binding sites of Caesium atom in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution (pdb code 7lut). This binding sites where shown within 5.0 Angstroms radius around Caesium atom.
In total 7 binding sites of Caesium where determined in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution, PDB code: 7lut:
Jump to Caesium binding site number: 1; 2; 3; 4; 5; 6; 7;

Caesium binding site 1 out of 7 in 7lut

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Caesium binding site 1 out of 7 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 1 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cs304

b:22.6
occ:0.60
 O A:HOH573 2.8 37.1 1.0
O A:ALA167 3.0 16.2 1.0
O A:GLY170 3.1 16.2 1.0
O A:HIS204 3.4 19.2 1.0
O A:HOH534 3.6 15.2 0.4
O A:HOH461 3.9 37.0 1.0
N A:ALA206 4.0 15.3 1.0
NH1 A:ARG171 4.1 19.8 1.0
C A:ALA167 4.2 15.9 1.0
C A:GLY170 4.2 13.9 1.0
O A:HOH437 4.2 12.2 0.3
O A:SER168 4.2 17.6 1.0
CD A:ARG171 4.3 16.9 1.0
C A:ALA205 4.4 15.9 1.0
CA A:ALA205 4.4 16.0 1.0
O A:HOH481 4.5 38.2 1.0
C A:HIS204 4.5 19.4 1.0
C A:SER168 4.7 17.1 1.0
CZ A:ARG171 4.8 19.4 1.0
CA A:ALA206 4.8 14.5 1.0
O A:HOH619 4.9 42.9 1.0
NE A:ARG171 4.9 18.9 1.0
CA A:SER168 4.9 17.2 1.0
N A:GLY170 4.9 14.5 1.0
CB A:ALA206 5.0 14.2 1.0
N A:ALA205 5.0 18.0 1.0
N A:SER168 5.0 16.4 1.0

Caesium binding site 2 out of 7 in 7lut

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Caesium binding site 2 out of 7 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 2 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cs408

b:14.7
occ:0.92
 O B:THR71 3.0 11.3 1.0
O B:HOH638 3.1 21.1 1.0
O B:THR69 3.1 14.1 1.0
OG1 B:THR66 3.2 13.6 1.0
O B:THR66 3.2 14.2 1.0
O B:HOH556 3.4 24.5 1.0
O B:HOH844 3.7 25.0 1.0
CB B:THR66 3.8 13.0 1.0
C B:THR66 3.9 14.1 1.0
C B:THR69 4.1 13.5 1.0
C B:THR71 4.1 10.8 1.0
OG1 B:THR69 4.2 12.6 1.0
N B:THR69 4.5 15.2 1.0
N B:THR71 4.5 11.0 1.0
CA B:THR66 4.5 13.6 1.0
N B:ALA67 4.6 14.6 1.0
CA B:ALA67 4.6 15.8 1.0
O B:HOH683 4.6 11.7 1.0
N B:GLY68 4.8 17.5 1.0
CA B:THR69 4.9 14.0 1.0
N B:ARG70 4.9 13.5 1.0
C B:ARG70 4.9 12.3 1.0
CA B:ARG70 4.9 13.2 1.0
CA B:THR71 5.0 11.1 1.0
N B:THR72 5.0 10.8 1.0
C B:ALA67 5.0 16.7 1.0

Caesium binding site 3 out of 7 in 7lut

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Caesium binding site 3 out of 7 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 3 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cs409

b:13.2
occ:0.83
 CS B:CS409 0.0 13.2 0.8
CS B:CS409 2.5 26.9 0.2
O B:GLY232 2.9 13.0 1.0
O B:PHE306 2.9 12.8 1.0
O B:GLY268 3.0 9.9 1.0
O B:LEU304 3.3 11.3 1.0
O B:SER308 3.3 11.6 1.0
C B:GLY232 3.8 10.8 1.0
O B:VAL231 3.9 10.2 1.0
C B:PHE306 4.0 13.4 1.0
CA B:GLY232 4.0 10.5 1.0
C B:GLY268 4.0 10.1 1.0
CD B:PRO270 4.1 11.1 1.0
N B:PHE306 4.2 12.8 1.0
CB B:PHE306 4.3 13.9 1.0
C B:LEU304 4.4 11.2 1.0
CA B:PHE306 4.5 13.5 1.0
CD B:PRO257 4.5 8.8 1.0
CG B:PRO270 4.5 11.6 1.0
CA B:GLY268 4.5 10.5 1.0
C B:SER308 4.5 11.8 1.0
CG B:PRO257 4.6 9.0 1.0
C B:VAL231 4.7 9.7 1.0
N B:SER308 4.9 12.7 1.0
N B:GLY232 4.9 10.0 1.0
OE2 B:GLU256 5.0 9.7 1.0

Caesium binding site 4 out of 7 in 7lut

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Caesium binding site 4 out of 7 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 4 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cs409

b:26.9
occ:0.17
 CS B:CS409 0.0 26.9 0.2
CS B:CS409 2.5 13.2 0.8
OE2 B:GLU256 2.9 9.7 1.0
O B:VAL231 3.2 10.2 1.0
O B:GLY268 3.4 9.9 1.0
O B:GLY232 3.6 13.0 1.0
CD B:PRO270 3.7 11.1 1.0
CG1 B:VAL231 3.8 9.3 1.0
CD B:GLU256 3.8 9.7 1.0
O B:SER308 3.8 11.6 1.0
CG B:GLU256 3.8 9.4 1.0
CB B:VAL309 3.9 11.0 1.0
CG2 B:VAL309 4.0 10.9 1.0
CG B:PRO270 4.0 11.6 1.0
C B:VAL231 4.1 9.7 1.0
CB B:GLU256 4.3 8.9 1.0
CB B:VAL231 4.4 9.1 1.0
C B:GLY232 4.4 10.8 1.0
C B:GLY268 4.5 10.1 1.0
CD B:PRO257 4.6 8.8 1.0
CA B:GLY232 4.6 10.5 1.0
N B:PRO270 4.7 10.8 1.0
C B:SER308 4.7 11.8 1.0
CA B:VAL309 4.8 10.8 1.0
CA B:GLU256 4.8 8.6 1.0
N B:GLY232 4.8 10.0 1.0
CA B:ALA269 4.8 10.5 1.0
CA B:VAL231 4.9 9.1 1.0
CG1 B:VAL309 5.0 11.1 1.0

Caesium binding site 5 out of 7 in 7lut

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Caesium binding site 5 out of 7 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 5 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cs413

b:40.8
occ:0.51
 O B:HOH833 2.5 19.5 0.4
O B:HOH833 2.8 15.4 0.6
O B:HOH687 3.0 21.6 1.0
O B:HOH573 3.0 34.1 1.0
O B:SER297 3.0 15.9 1.0
OD1 B:ASP305 3.2 17.0 1.0
O B:HOH804 3.6 31.1 1.0
OD2 B:ASP305 3.6 17.7 1.0
CG B:ASP305 3.7 16.1 1.0
O B:HOH675 3.9 54.2 1.0
C B:SER297 3.9 14.8 1.0
OG B:SER297 4.0 16.2 1.0
N B:SER297 4.1 16.7 1.0
CG2 B:THR165 4.2 23.1 1.0
OE2 B:GLU296 4.2 36.0 1.0
OG1 B:THR165 4.2 24.8 1.0
CA B:SER297 4.5 15.5 1.0
O B:HOH707 4.5 22.5 1.0
CD B:GLU296 4.6 32.1 1.0
CB B:THR165 4.8 23.2 1.0
CB B:GLU296 4.8 22.2 1.0
C B:GLU296 4.8 18.1 1.0
CA B:GLU296 4.8 20.1 1.0
OE1 B:GLU296 4.9 31.1 1.0
CB B:SER297 4.9 15.6 1.0
N B:TYR298 5.0 13.6 1.0
O B:ASP305 5.0 13.2 1.0

Caesium binding site 6 out of 7 in 7lut

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Caesium binding site 6 out of 7 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 6 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cs414

b:15.4
occ:0.34
 O B:PRO56 3.1 9.2 1.0
O B:GLY54 3.2 11.6 1.0
C2 B:DMS402 3.5 22.6 1.0
O B:HOH726 3.7 20.9 1.0
O B:HOH691 4.0 15.5 1.0
O B:DMS402 4.0 23.8 1.0
C B:PRO56 4.3 9.2 1.0
C B:GLY54 4.4 10.9 1.0
S B:DMS402 4.4 25.2 1.0
N B:PRO56 4.6 9.7 1.0
C B:ARG55 4.7 9.6 1.0
C1 B:DMS402 4.8 22.6 1.0
CD B:PRO56 4.8 10.0 1.0
O B:ARG55 4.9 10.0 1.0

Caesium binding site 7 out of 7 in 7lut

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Caesium binding site 7 out of 7 in the The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 7 of The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta- Site at 1.60 Angstrom Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cs415

b:21.9
occ:0.50
 O B:LYS99 3.0 15.3 1.0
O B:HOH821 3.0 31.0 1.0
C B:LYS99 3.9 14.6 1.0
CA B:LYS99 4.6 14.5 1.0
CB B:LYS99 4.7 16.4 1.0
CA B:GLY102 4.8 17.2 1.0
N B:ARG100 4.8 15.0 1.0

Reference:

E.Hilario, M.F.Dunn, L.J.Mueller. The Internal Aldimine Form of the Wild-Type Salmonella Typhimurium Tryptophan Synthase in Complex with Cesium Ion at the Metal Coordination Site and the Product L-Tryptophan at the Enzyme Beta-Site at 1.60 Angstrom Resolution. To Be Published.
Page generated: Tue Jul 30 21:17:04 2024

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