Caesium in PDB 4jtc: Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+

The structure of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+, PDB code: 4jtc was solved by A.Banerjee, A.Lee, E.Campbell, R.Mackinnon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.56
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	145.434, 145.434, 285.591, 90.00, 90.00, 90.00
R / Rfree (%)	23.7 / 26.2

The binding sites of Caesium atom in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ (pdb code 4jtc). This binding sites where shown within 5.0 Angstroms radius around Caesium atom.
In total 8 binding sites of Caesium where determined in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+, PDB code: 4jtc:
Jump to Caesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Caesium binding site 1 out of 8 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 1 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs501 b:45.6 occ:0.50 O B:GLY372 3.5 41.9 1.0 O B:TYR373 3.6 39.9 1.0 C B:TYR373 3.9 40.6 1.0 CA B:TYR373 4.4 40.4 1.0 N B:GLY374 4.5 41.6 1.0 C B:GLY372 4.6 40.5 1.0 CS B:CS502 4.8 43.9 0.5 CA B:GLY374 4.8 42.4 1.0 N B:TYR373 5.0 39.9 1.0

Caesium binding site 2 out of 8 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 2 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs502 b:43.9 occ:0.50 O B:VAL371 3.6 40.0 1.0 O B:THR370 3.9 37.7 1.0 O B:GLY372 4.0 41.9 1.0 C B:VAL371 4.1 39.1 1.0 N B:GLY372 4.6 39.0 1.0 C B:GLY372 4.6 40.5 1.0 CS B:CS503 4.6 0.1 0.5 CA B:GLY372 4.7 39.9 1.0 CS B:CS501 4.8 45.6 0.5 CA B:VAL371 4.8 38.3 1.0

Caesium binding site 3 out of 8 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 3 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs503 b:0.1 occ:0.50 O B:THR370 3.6 37.7 1.0 OG1 B:THR370 3.7 36.5 1.0 CB B:THR370 4.2 39.8 1.0 C B:THR370 4.4 37.9 1.0 CS B:CS502 4.6 43.9 0.5

Caesium binding site 4 out of 8 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 4 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ within 5.0Å range:

Caesium binding site 5 out of 8 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 5 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ within 5.0Å range: probe atom residue distance (Å) B Occ H:Cs501 b:85.3 occ:0.50 O H:GLY372 3.6 99.5 1.0 O H:TYR373 3.8 0.7 1.0 NZ Y:LYS27 3.9 0.9 0.3 C H:TYR373 4.0 0.2 1.0 CA H:TYR373 4.4 99.8 1.0 C H:GLY372 4.5 99.8 1.0 N H:GLY374 4.6 0.3 1.0 CS H:CS502 4.9 74.5 0.5 N H:TYR373 4.9 99.9 1.0 CA H:GLY374 5.0 0.3 1.0

Caesium binding site 6 out of 8 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 6 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ within 5.0Å range: probe atom residue distance (Å) B Occ H:Cs502 b:74.5 occ:0.50 O H:THR370 3.7 95.9 1.0 O H:VAL371 3.7 96.7 1.0 CS H:CS503 3.9 75.2 0.5 C H:VAL371 4.2 96.7 1.0 CA H:VAL371 4.8 95.9 1.0 C H:THR370 4.8 94.7 1.0 N H:GLY372 4.8 98.0 1.0 O H:GLY372 4.8 99.5 1.0 CS H:CS501 4.9 85.3 0.5

Caesium binding site 7 out of 8 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 7 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ within 5.0Å range: probe atom residue distance (Å) B Occ H:Cs503 b:75.2 occ:0.50 O H:THR370 3.7 95.9 1.0 OG1 H:THR370 3.7 91.7 1.0 CS H:CS502 3.9 74.5 0.5 CB H:THR370 4.3 92.3 1.0 C H:THR370 4.5 94.7 1.0

Caesium binding site 8 out of 8 in the Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 8 of Crystal Structure of KV1.2-2.1 Paddle Chimera Channel in Complex with Charybdotoxin in Cs+ within 5.0Å range:

A.Banerjee, A.Lee, E.Campbell, R.Mackinnon. Structure of A Pore-Blocking Toxin in Complex with A Eukaryotic Voltage-Dependent K(+) Channel. Elife V. 2 00594 2013.
ISSN: ESSN 2050-084X
PubMed: 23705070
DOI: 10.7554/ELIFE.00594