Caesium in PDB 4ila: The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium

The structure of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium, PDB code: 4ila was solved by L.Sauguet, P.J.Corringer, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.98 / 3.50
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	182.404, 133.232, 160.177, 90.00, 102.50, 90.00
R / Rfree (%)	19 / 20.8

The structure of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium also contains other interesting chemical elements:

Chlorine

(Cl)

5 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 27;

Binding sites:

The binding sites of Caesium atom in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium (pdb code 4ila). This binding sites where shown within 5.0 Angstroms radius around Caesium atom.
In total 27 binding sites of Caesium where determined in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium, PDB code: 4ila:
Jump to Caesium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Caesium binding site 1 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 1 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs407 b:0.8 occ:1.00 OG1 A:THR226 4.1 73.9 1.0 OG1 B:THR226 4.1 60.6 1.0 OG1 C:THR226 4.1 68.7 1.0 OG1 E:THR226 4.4 77.5 1.0 OG1 D:THR226 4.5 73.2 1.0

Caesium binding site 2 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 2 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs408 b:0.9 occ:1.00 O A:ASP178 3.0 91.8 1.0 OD1 A:ASP178 4.2 0.5 1.0 C A:ASP178 4.2 89.3 1.0 CG A:ASP178 4.3 0.1 1.0 CB A:ASP178 4.5 89.5 1.0 CA A:ASP178 4.9 86.1 1.0 OD2 A:ASP178 4.9 0.6 1.0

Caesium binding site 3 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 3 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs409 b:0.2 occ:1.00 O A:LYS151 2.9 93.0 1.0 OH A:TYR23 3.5 0.9 1.0 OD2 A:ASP153 3.9 0.4 1.0 C A:LYS151 4.0 92.2 1.0 OD1 A:ASP153 4.0 0.7 1.0 CG A:ASP153 4.1 0.6 1.0 N A:ASP153 4.3 0.4 1.0 CZ A:TYR23 4.4 96.3 1.0 CA A:ASN152 4.4 94.1 1.0 CE1 A:TYR23 4.4 84.3 1.0 C A:ASN152 4.6 0.8 1.0 N A:ASN152 4.6 92.0 1.0 N A:LYS151 4.8 83.7 1.0

Caesium binding site 4 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 4 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs410 b:0.8 occ:1.00 O A:ALA87 2.9 0.3 1.0 OD1 A:ASP88 3.4 1.0 1.0 C A:ALA87 3.8 0.7 1.0 CG A:ASP88 4.0 0.7 1.0 N A:ALA87 4.2 95.0 1.0 OD2 A:ASP88 4.2 0.8 1.0 CA A:ALA87 4.6 95.6 1.0 N A:ASP88 4.7 1.0 1.0 OD1 A:ASP86 4.8 0.4 1.0 CA A:ASP88 4.8 0.3 1.0 C A:ASP86 4.9 96.6 1.0 CG A:ASP86 4.9 0.5 1.0

Caesium binding site 5 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 5 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs411 b:0.6 occ:1.00 O A:VAL149 3.2 89.2 1.0 O A:LEU146 4.0 95.7 1.0 O A:GLU147 4.2 96.5 1.0 C A:VAL149 4.3 87.1 1.0 C A:GLU147 4.5 96.1 1.0 CA A:GLU147 4.8 92.5 1.0 N A:VAL149 4.9 82.1 1.0 CA A:GLY150 4.9 82.9 1.0

Caesium binding site 6 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 6 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs412 b:0.3 occ:1.00 O A:ILE71 2.6 97.5 1.0 O A:PRO68 3.1 0.7 1.0 CG2 A:VAL5 3.8 0.7 1.0 C A:ILE71 3.8 95.5 1.0 N A:ILE73 4.1 86.5 1.0 C A:PRO68 4.1 0.5 1.0 CA A:TRP72 4.2 90.5 1.0 O A:GLU69 4.2 99.9 1.0 CA A:GLU69 4.3 99.3 1.0 N A:TRP72 4.4 91.0 1.0 C A:GLU69 4.5 0.6 1.0 C A:TRP72 4.5 93.2 1.0 N A:GLU69 4.6 0.2 1.0 CD1 A:ILE73 4.7 88.6 1.0 CB A:ILE73 4.7 85.5 1.0 CG1 A:ILE73 4.7 85.4 1.0 N A:ILE71 4.8 90.8 1.0 CB A:VAL5 4.9 0.6 1.0 CA A:ILE71 4.9 89.7 1.0 CA A:ILE73 5.0 83.1 1.0

Caesium binding site 7 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 7 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ A:Cs413 b:0.5 occ:1.00 O A:ARG85 3.0 88.3 1.0 O A:ALA84 3.0 83.1 1.0 C A:ARG85 3.6 87.6 1.0 C A:ALA84 3.7 83.0 1.0 N A:ASP86 4.0 87.5 1.0 CA A:ASP86 4.1 89.9 1.0 CB A:ALA84 4.1 80.5 1.0 N A:ARG85 4.4 79.5 1.0 CA A:ALA84 4.4 79.4 1.0 CA A:ARG85 4.5 79.6 1.0 CB A:ASP86 4.8 93.2 1.0 N A:ALA84 4.9 80.0 1.0

Caesium binding site 8 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 8 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs407 b:0.4 occ:1.00 O B:LYS151 3.0 89.0 1.0 OH B:TYR23 3.5 86.9 1.0 OD2 B:ASP153 3.9 0.7 1.0 OD1 B:ASP153 4.0 0.2 1.0 C B:LYS151 4.0 87.4 1.0 CG B:ASP153 4.2 0.4 1.0 CZ B:TYR23 4.4 83.3 1.0 N B:ASP153 4.4 96.0 1.0 CE1 B:TYR23 4.5 76.2 1.0 CA B:ASN152 4.5 86.8 1.0 N B:ASN152 4.7 86.0 1.0 C B:ASN152 4.7 94.6 1.0 N B:LYS151 4.9 76.8 1.0

Caesium binding site 9 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 9 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs408 b:0.8 occ:1.00 O B:VAL149 2.8 81.2 1.0 O B:LEU146 3.7 93.5 1.0 C B:VAL149 4.0 80.4 1.0 O B:GLU147 4.4 94.8 1.0 C B:GLU147 4.6 93.7 1.0 N B:VAL149 4.7 77.1 1.0 CA B:GLY150 4.7 76.7 1.0 N B:GLY150 4.8 77.0 1.0 C B:LEU146 4.8 93.6 1.0 CA B:GLU147 4.9 90.2 1.0 CA B:VAL149 5.0 74.8 1.0

Caesium binding site 10 out of 27 in the The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium


Mono view


Stereo pair view

A full contact list of Caesium with other atoms in the Cs binding site number 10 of The Pentameric Ligand-Gated Ion Channel Glic A237F in Complex with Cesium within 5.0Å range: probe atom residue distance (Å) B Occ B:Cs409 b:0.6 occ:1.00 OD1 B:ASP88 3.4 0.5 1.0 O B:ALA87 3.4 0.5 1.0 CG B:ASP88 4.0 0.5 1.0 OD2 B:ASP88 4.2 0.9 1.0 C B:ALA87 4.3 99.0 1.0 N B:ALA87 4.6 93.2 1.0 OD1 B:ASP86 4.9 0.2 1.0 CG B:ASP86 5.0 0.8 1.0

L.Sauguet, F.Poitevin, S.Murail, C.Van Renterghem, G.Moraga-Cid, L.Malherbe, A.W.Thompson, P.Koehl, P.J.Corringer, M.Baaden, M.Delarue. Structural Basis For Ion Permeation Mechanism in Pentameric Ligand-Gated Ion Channels. Embo J. V. 32 728 2013.
ISSN: ISSN 0261-4189
PubMed: 23403925
DOI: 10.1038/EMBOJ.2013.17